Skip to main content
Figure 7 | Journal of Neuroinflammation

Figure 7

From: Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

Figure 7

Neuromelanin-induced caspase-3 and -8 activities. Caspase 3 and 8 activities were assessed using the Caspase-Glo® Assay (Promega). Results are mean ± standard deviation of at least three independent experiments, and are expressed as percentage of control values. Statistical analysis: one-way ANOVA followed by the least significant difference post-hoc test for multiple comparisons. α = 0.05 was used. *, P < 0.05; **, P < 0.01 compared with the control group; a, compared with the same treatment without the inhibitor IETD-fmk, P < 0.01. Cont., control; LPS, lipopolysaccharide; LPS + I, lipopolysaccharide plus IETD-fmk; NM, neuromelanin; NM + I, neuromelanin plus IETD-fmk.

Back to article page