GW0742 treatment increased the ratio of microglia/A
β immunoreactivity. Figure (A) shows a typical confocal image of microglia surrounding 6E10 immunopositive extracellular Aβ deposit (B) in vehicle-treated mice. Figure (C) is the overlay of (A) and (B). Figure (D) shows a typical example of Iba-1 positive microglia in GW742-treated mice surrounding the Aβ deposits (E). Figure (F) is the overlay of (D) and (E). Scale bar = 100 μm. GW0742 treatment increased the ratio of Iba-1/6E10 immunoreactivity (G) and decreased Iba-1 immunoreactivity in areas devoid of 6E10 immunoreactivity (H). Figures (I) and (J) with high magnification insets depict the quantified Iba-1 immunoreactive areas outside the areas of 6E10 immunoreactivity in vehicle (I) and GW0742 treated (J) mice. Scale bar = 400 μm. Results are presented as mean ± SEM. VEH = vehicle- and GW0742 = GW0742-treated mice. *P < 0.05 as analyzed by Student’s t-test. n = 7 in vehicle- and n = 9 in GW0742-treated group.