TY - JOUR AU - Fu, Shou-Peng AU - Wang, Jian-Fa AU - Xue, Wen-Jing AU - Liu, Hong-Mei AU - Liu, Bing-run AU - Zeng, Ya-Long AU - Li, Su-Nan AU - Huang, Bing-Xu AU - Lv, Qing-Kang AU - Wang, Wei AU - Liu, Ju-Xiong PY - 2015 DA - 2015/01/17 TI - Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms JO - Journal of Neuroinflammation SP - 9 VL - 12 IS - 1 AB - Accumulating evidence suggests that neuroinflammation plays an important role in the progression of Parkinson’s disease (PD). Excessively activated microglia produce several pro-inflammatory enzymes and pro-inflammatory cytokines, leading to damage to surrounding neurons and eventually inducing neurodegeneration. Therefore, the inhibition of microglial overactivation may be a potential therapeutic strategy to prevent the further progression of PD. β-Hydroxybutyric acid (BHBA) has been shown to suppress lipopolysaccharide (LPS)-induced inflammation in BV-2 cells and to protect dopaminergic neurons in previous studies, but the underlying mechanisms remain unclear. Thus, in this study, we further investigated this mechanism in LPS-induced in vivo and in vitro PD models. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-014-0230-3 DO - 10.1186/s12974-014-0230-3 ID - Fu2015 ER -