Figure 3
Impact of AMD3100 treatment on functional recovery after photothrombosis. Neurological outcome was assessed by a composite neuroscore in CX3CR1 wild-type mice before and on days 1, 2, 7 and 14 after photothrombosis (PT). The following numbers of animals were included: PT/AMD3100, n = 13; PT/vehicle, n = 14; sham/AMD3100, n = 9; sham/vehicle, n = 10. (A) Percentage of improvement in outcome in mice treated either with saline or AMD3100 from day (d)7 to d14 and (B) from d1 to d14 after PT. Statistical analysis was performed by Mann–Whitney U-test, and differences are indicated in the figure.