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Table 1 Composite neuroscore for quantification of neurological deficits before and after photothrombotic stroke at days 1, 2, 7 and 14

From: Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke

Test

Score and description

Left forelimb flexion in suspension

0 - impaired paw is not moving and tightly held to the trunk

1 - impaired paw mostly held to the trunk, slightly movable

2 - impaired paw moves up and down, asymmetry to other paw

3 - slight asymmetry between the paws, both paws well movable

4 - normal, symmetric

Paw placement of the left side

0 - paw totally immobilized, hanging down, no movement

1 - paw hanging, but little movement back and forth (horizontal plane)

2 - paw hanging, horizontal and vertical movement below table level

3 - paw hanging horizontal and vertical movement up to table surface level

4 - paw hanging, mobile in all directions, reaching the table surface

5 - normal, paw is immediately taken up to the table surface

Whisker-reflex, left side

0 - not present

2 - present

Faults of the left forelimb walking 27 steps on a grid, 46.5 cm long, step size 2 mm, interspace 1.5 cm (2–3 training sessions)

0 - 6 faults or more

1 - 5 faults

2 - 4 faults

3 - 3 faults

4 - 2 faults

5 - 1 fault

6 - no fault step

  1. Before photothrombosis, the animal should achieve 22 points, at day 1 < 11 points, otherwise the animal was excluded from the study.