NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

Table 2 Numbers and rates of animals with seizures during the first 24 h postsurgery and on the 6th week post-treatment in experimental groups

(a) Results from sham and temporal lobe epilepsy rats after 6 weeks of treatment with NLRP1 siRNA or control siRNA
	Within 24 h post-stimulation		On the 6th week post-treatment
	Number	Rate (%)	Number	Rate (%)
Sham + Control siRNA	0/18	0	0/18	0
Sham + NLRP1 siRNA	0/18	0	0/18	0
TLE + Control siRNA	18/18	100	14/18	77.8
TLE + NLRP1 siRNA	18/18	100	8/18	44.4^a
(b) Results from sham and TLE rats after 6 weeks of treatment with Caspase-1 siRNA or control siRNA
Sham + Control siRNA	0/18	0	0/18	0
Sham + Caspase-1 siRNA	0/18	0	0/18	0
TLE + Control siRNA	18/18	100	14/18	77.8
TLE + Caspase-1 siRNA	18/18	100^b	7/18	38.9^b

ISSN: 1742-2094