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Table 2 Numbers and rates of animals with seizures during the first 24 h postsurgery and on the 6th week post-treatment in experimental groups

From: NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(a) Results from sham and temporal lobe epilepsy rats after 6 weeks of treatment with NLRP1 siRNA or control siRNA
  Within 24 h post-stimulation On the 6th week post-treatment
Number Rate (%) Number Rate (%)
Sham + Control siRNA 0/18 0 0/18 0
Sham + NLRP1 siRNA 0/18 0 0/18 0
TLE + Control siRNA 18/18 100 14/18 77.8
TLE + NLRP1 siRNA 18/18 100 8/18 44.4a
(b) Results from sham and TLE rats after 6 weeks of treatment with Caspase-1 siRNA or control siRNA
Sham + Control siRNA 0/18 0 0/18 0
Sham + Caspase-1 siRNA 0/18 0 0/18 0
TLE + Control siRNA 18/18 100 14/18 77.8
TLE + Caspase-1 siRNA 18/18 100b 7/18 38.9b
  1. a P <0.01 (versus TLE + Control siRNA).
  2. b P <0.01 (versus TLE + Control siRNA).