Figure 4

Pial arteriolar dilating reponses. Animals were treated with vehicle or FTY720 (0.5 mg/kg) 3 hours post-surgery. Measurements were done at 48 hours after. Compared to SAH-vehicle, SAH-FTY720 animals had improved pial arteriolar vasodilating responses to all the vasodilators tested. (A) hypercapnia (PaCO₂ at approximately 70 mmHg) (P < 0.001). (B) acetylcholine, Ach (*P = 0.003; **P = 0.002). (C) adenosine, ADO (*P = 0.002; **P < 0.001). (D) S-nitroso-N-acetyl penicillamine, SNAP (*P = 0.007; **P < 0.001). Bars represent means ± SEM. n = 5 to 6 each group. Significance was determined using ANOVA.