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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

Figure 5

mTBI induces an elevation in astrocyte number in ipsilateral cerebral cortex that is inhibited by 3,6′-dithiothalidomide. At 72 h post injury, cerebral cortex ipsilateral to mTBI was assessed for cellular changes. (A) and (B) Astrocyte number (GFAP - red) was increased post mTBI (p < 0.001). Treatment with 3,6′-dithiothalidomide at 1 h post-injury prevented this. (A) and (C) No difference in total number of cells was evident between groups, as revealed from DAPI (blue) staining. Within (A) (representative sections within the cerebral cortex), the bar is equal to 100 μm in length.

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