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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

Figure 6

mTBI induces an elevation in astrocyte number in ipsilateral dentate gyrus that is inhibited by 3,6′-dithiothalidomide. At 72 h post injury, dentate gyrus ipsilateral injury was assessed for cellular changes. (A) and (B) Astrocyte number (GFAP - red) was elevated post mTBI (p < 0.001). Treatment with 3,6′-dithiothalidomide at 1 h post-injury inhibited this. (A) and (C) No difference in total number of cells was apparent between groups, as evaluated by DAPI (blue) staining. Within (A) (representative sections within the dentate gyrus), the bar is equal to 100 μm in length.

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Journal of Neuroinflammation

ISSN: 1742-2094