DAMP/PAMP | TRP channel/s | Immune cells | Non-immune cells | Type of inflammasome | Reference |
---|---|---|---|---|---|
Acid pH | TRPV1 | Macrophages | Â | NLRP3 | [39] |
Cold | TRPM8 | PBMCs | Neurons | ? | [44] |
Liposome/crystals | TRPM2 | Phagocytes | Â | NLRP3 | [123] |
RVD | TRPV2 | Macrophages | Â | NLRP3 | [128] |
TRPM7 | Macrophages | Â | NLRP3 | [60] | |
Osmotic stress | TRPV2 | Dendritic cells | Â | NLRP3 | [16] |
MSU/alum | TRPV2 | Monocytes | Â | NLRP3 | [59] |
TRPA1 | Â | Sensory neurons | ? | [100] | |
TRPV1 | Â | Neurons | ? | [100] | |
ATP | P2Y2/TRPV1 | Â | Sensory Neurons | ? | [98] |
miRNA | TLR7/TRPA1 | Â | Sensory neurons | ? | [91] |
Mechanical stretch | TRPC3 | Monocytes | Â | ? | [129] |
Ca2+ | TLR4-TRPC6 | Â | Endothelial cells | ? | [70] |
RV | TRPA1 | Â | Neuroblastomas | NLRP3 | [76] |
TRPV1 | Â | Â | Â | Â | |
TRPM8 | Â | Â | Â | Â | |
RSV/MS | TLR2/4-TRPV1 | Â | Epithelial cells | NLRP3 | [76] |
TLR2/TRPA1 | Â | Smooth muscle cells | NLRP3 | [76] | |
TLR2/4-TRPM8 | Â | Neuroblastomas | NLRP3 | [76] | |
PG | TLR2/4-TRPV1 | Monocytes | Â | NLRP3 | [74] |
 | Macrophages |  | AIM2 | [74] | |
TLR4-TRPV1 | Â | Sensory neurons | ? | ||
LPS | TLR4/TRPC6 | Â | Sensory Neurons | ? | [70] |