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Table 1 DAMP/PAMP recognition by TRP channels and PRRs triggers the inflammasome activation in immune and neuron cells

From: Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

DAMP/PAMP

TRP channel/s

Immune cells

Non-immune cells

Type of inflammasome

Reference

Acid pH

TRPV1

Macrophages

 

NLRP3

[39]

Cold

TRPM8

PBMCs

Neurons

?

[44]

Liposome/crystals

TRPM2

Phagocytes

 

NLRP3

[123]

RVD

TRPV2

Macrophages

 

NLRP3

[128]

TRPM7

Macrophages

 

NLRP3

[60]

Osmotic stress

TRPV2

Dendritic cells

 

NLRP3

[16]

MSU/alum

TRPV2

Monocytes

 

NLRP3

[59]

TRPA1

 

Sensory neurons

?

[100]

TRPV1

 

Neurons

?

[100]

ATP

P2Y2/TRPV1

 

Sensory Neurons

?

[98]

miRNA

TLR7/TRPA1

 

Sensory neurons

?

[91]

Mechanical stretch

TRPC3

Monocytes

 

?

[129]

Ca2+

TLR4-TRPC6

 

Endothelial cells

?

[70]

RV

TRPA1

 

Neuroblastomas

NLRP3

[76]

TRPV1

    

TRPM8

    

RSV/MS

TLR2/4-TRPV1

 

Epithelial cells

NLRP3

[76]

TLR2/TRPA1

 

Smooth muscle cells

NLRP3

[76]

TLR2/4-TRPM8

 

Neuroblastomas

NLRP3

[76]

PG

TLR2/4-TRPV1

Monocytes

 

NLRP3

[74]

 

Macrophages

 

AIM2

[74]

TLR4-TRPV1

 

Sensory neurons

?

[88,93]

LPS

TLR4/TRPC6

 

Sensory Neurons

?

[70]

  1. ?, Suggested, but not yet identified; AIM2, absent in melanoma 2; DAMP, danger-associated molecular pattern; LPS, lipopolysaccharide; MSU, monosodium urate; MV, Measles virus; NLRP3, NOD-like receptor family, pyrin domain-containing 3; P2Y2, Purinergic receptor P2Y G-protein coupled 2; PAMP, pathogen-associated molecular pattern; PBMC, peripheral blood mononuclear cell; PG, Porphyromonas gingivalis; RV, Rhinovirus; RSV, Respiratory syncytial virus; RVD, regulatory volume decrease; TLR, Toll-like receptor; TRP, transient receptor potential; TRPM2, TRP Melastatin type-2; TRPM7, TRP Melastatin type 7; TRPM8, TRP Melastatin type-8; TRPA1, TRP Ankyrin-like protein with transmembrane-like domain 1; TRPC3, TRP Canonical type-3, TRPV1, TRP vanilloid type-1; TRPV2, TRP Vanilloid type-2.