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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

Figure 4

Expression of tight junction proteins and matrix metalloproteinases at four weeks after stroke. A. Western blot analysis for TJPs. ZO-1: **P <0.05 versus V-I, V-C and Mino-C. Occludin: *P <0.05 versus V-I, V-C and Mino-C. Claudin-5: *P <0.05 versus V-I, V-C and Mino-C. B. Gel zymography analysis for MMP-2 and −9. **P <0.01 versus V-C and Mino-C. n = 8 in the vehicle group, 9 in the minocycline group. C. Western blot analysis for MMP-3. Level of MMP-3 including preform (57 kDa) and active form (45 kDa): *P <0.05 versus V-C and Mino-C. Mino-C: minocycline contralateral. Mino-I: minocycline ipsilateral. V-C: Vehicle contralateral. V-I: Vehicle ipsilateral. n = 8 in the vehicle group, 9 in the minocycline group.

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Journal of Neuroinflammation

ISSN: 1742-2094