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Figure 3 | Journal of Neuroinflammation

Figure 3

From: MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway

Figure 3

A putative target site of miR-27a located in the 3′-UTR of TICAM-2 mRNA was predicted by bioinformatics analysis. (a) The predicted miR-27a binding site in the 3′-untranslated region (UTR) of TICAM-2 in rats. (b) PCR analysis confirming TICAM-2 mRNA was abnormally expressed at both 24 and 72 hours after spinal cord ischemia reperfusion (IR). The profiles of TICAM-2 were expressed in an opposite manner as those of miR-27a. Relative expression is the change in expression compared to the sham-operated group at either 24 or 72 hours after reperfusion. Data are expressed as mean ± SEM. **P <0.05 versus the sham group. Results shown are representative data from three separate experiments.

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Journal of Neuroinflammation

ISSN: 1742-2094