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Figure 6 | Journal of Neuroinflammation

Figure 6

From: MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway

Figure 6

Effects of intrathecal injection of mimic-27a and AMO-27a on blood-spinal cord barrier (BSCB) integrity after ischemia reperfusion (IR). (a) Effects of intrathecal injection of mimic-27a and AMO-27a on BSCB permeability measured by Evans blue (EB) extravasation. Almost no red fluoresce was seen in the spinal cord of the sham group at 24 and 72 hours after IR. Compared with the IR group, EB extravasation (red) was significantly lower in rats who received an intrathecal injection of mimic-27a. Conversely, at 24 hours after injury, much more red fluorescence, especially in the gray matter, was seen in rats who received an intrathecal injection of AMO-27a, which was even stronger at 72 hours post-injury. (b) The EB content of the spinal cord (μg/g). (c) Quantification of EB fluorescence density (INT/mm2) . Original magnification, 100×; Scale bar = 50 μm. **P <0.05 versus the sham group; ## P <0.05 versus the IR group.

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Journal of Neuroinflammation

ISSN: 1742-2094