MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway

Table 2 MicroRNAs (miRs) that were differentially expressed in the spinal cord of rats 72 hours after ischemia reperfusion (IR) injury compared with that in the sham-operated rats (n = three per group)

	Average intensity of all probes (normalized)		Standard deviation
miR	IR-72 hours	Sham-72 hours	IR-72 hours	Sham-72 hours	Fold change	P value
Upregulated
rno-miR-144-3p	0.1945	0.8025	0.3912	0.2997	4.1246	0.0139
rno-miR-466c-3p	0.9230	1.5858	0.0982	0.2326	2.1179	0.0390
rno-miR-155-3p	0.1711	0.3344	0.0599	0.2500	4.1709	0.0201
rno-miR-200b-3p	0.0208	0.0627	0.1433	0.6803	3.1259	0.1591
Downregulated
rno-miR-10a-5p	6.0399	3.4597	0.1390	0.0936	0.4957	0.0076
rno-miR-27a-3p^a	1.1154	0.4575	0.0362	0.7307	0.3523	0.0276
rno-let-7a-5p^a	0.7267	0.4315	1.5856	0.7777	0.4905	0.0206
rno-miR-382-3p	2.8900	1.3146	0.1144	0.1230	0.4548	0.0017
rno-miR-21-5p	3.7967	1.6388	0.1440	0.0352	0.4316	0.0024
rno-miR-411-3p	1.8435	1.1789	0.0852	0.0306	0.4939	0.0020
rno-miR-547-5p	0.3345	0.1405	0.2538	0.5311	0.4201	0.0410
rno-miR-702-3p	0.3098	0.10918	0.3002	0.1005	0.4102	0.0206
rno-miR-10b-5p^a	17.174	11.0843	0.0650	0.0903	0.4645	0.0021
rno-miR-23b-3p^a	10.736	6.6908	0.0318	0.0805	0.4623	0.0003
rno-miR-221-3p	0.5148	0.2680	0.1642	0.2330	0.4520	0.0152
rno-miR-582-3p	0.1262	0.0664	0.1170	0.2453	0.4526	0.0092
rno-miR-100-5p	2.6130	1.3189	0.1617	0.2232	0.4504	0.0121
rno-miR-28-5p	0.0722	0.0402	0.2261	0.0853	0.4557	0.0295

Only the miRs with fold changes that were significantly different (upregulated >2.0 fold, downregulated <0.5 fold; P < 0.05) are shown.
^a##: miRs that were differentially expressed in the spinal cord at both 24 and 72 hours after IR.

ISSN: 1742-2094