LXR activity is reduced in the setting of CNS inflammation. Total RNA was isolated from the spinal cord of experimental allergic encephalomyelitis (EAE) and control mice 12 to 14 days post-induction. RNA levels (relative expression) for Lxra, Lxrb, Abcg1, Apoa1, Nos2, Il1b, Tnf and Il6 were measured by real-time RT-PCR. Control mice received complete Freund’s adjuvant and pertussis toxin without MOG. Line and error bars indicate median with interquartile range. Mann–Whitney test of significance.