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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression

Figure 7

Effect of methamphetamine on the expression of GFAP in vivo . (A) Effect of methamphetamine on the expression of GFAP in striatum isolated from methamphetamine-injected mice for 24 or 48 h. (B) Effect of methamphetamine on the expression of σ-1R in striatum isolated from methamphetamine-treated mice for 48 h. (C) Administration of methamphetamine in the WT mice induced the expression of GFAP but failed to increase GFAP expression in the σ-1R KO mice. All the data are mean ± SD, n = 3 per group. *P < 0.05 versus control group; #P < 0.05 versus methamphetamine-treated group in astrocytes from WT mice.

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Journal of Neuroinflammation

ISSN: 1742-2094