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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

Figure 1

Injection of viable hMSCs suppresses SCI symptoms in wild-type (WT) mice. (A) Motor function determined by BMS improved significantly after injection of viable hMSCs (filled circles, n = 67) compared with that of HBSS (open circles with solid line, n = 47) in WT mice. This improvement was diminished when unviable hMSCs were injected into WT mice (open circles with dashed line, n = 18) or when viable hMSCs were injected into Adcyap1 +/− mice (filled triangles, n = 17). Data are expressed as mean ± SEM. **P < 0.01 (Tukey post hoc t-test). (B) Typical images of lesion site after SCI. Injection of viable hMSCs (right upper) into WT mice decreased the lesion area compared with that in HBSS-treated control (left upper). Unviable hMSCs injected into WT mice (left bottom) and viable hMSCs injected into Adcyap1 +/− mice (right bottom) did not reduce the lesion size. R: rostral, C: caudal, D: dorsal, V: ventral. Scale bar is 500 μm. (C) Quantification of GFAP-unstained injury volume at 7 days. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01 (Tukey post hoc t-test). BMS Basso Mouse Scale, HBSS Hank’s balanced salt solution, MSC mesenchymal stem/stromal cell, n.s. no significant, PA +/− Adcyap1 (PACAP gene) heterozygous mice, SCI spinal cord injury, wt wild-type.

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