Figure 6

Schematic illustration of the putative neuroprotective mechanism underlying the effect of cross-talk between hMSCs and PACAP in animals subjected to SCI (see the ‘Discussions’ section) AAM alternatively activated (activating) macrophage, GFs growth factors, hMSCs human MSCs, IFNγ interferron-γ, IL interleikin, MG/MΦ microglia and/or macrophage, PACAP pituitary adenylate cyclase-activating polypeptide, PAC1R pituitary adenylate cyclase-activating polypeptide specific receptor, TGFβ transforming growth factor β, TNFα tumor necrosis factor α, TSG-6 tumor necrosis factor α-induced protein 6.