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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury

Figure 1

A scheme of the experimental paradigm. Male Lewis rats underwent CCI of the left sciatic nerve or sham operation on day 0 followed by subcutaneous immunization at the base of the tail. They were tested for pain hypersensitivity for 4 weeks (n = 6/group). On 10 and 30 days post-CCI, sciatic nerves (SNs), DRGs, and spinal cords (SCs) were collected for immunohistochemistry (n = 4/group) and spleens and lymph nodes for flow cytometry. For cytokine assay, SNs, DRGs, SCs, and serum were isolated from nerve-injured rats at 10 days post-CCI and from naïve rats (n = 6 to 7/group).

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Journal of Neuroinflammation

ISSN: 1742-2094