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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice

Figure 1

Castration stimulates thymus growth and CD4+ T cell production in male SOD1 G93A mice. (A) Wet weight of thymus of sham and castrated (Cx) SOD1G93A mice at 120 days. Data are mean ± SEM, n = 5, *P < 0.05 compared to sham group. (B) Representative scatter plot of flow cytometric analysis of CD4+ and CD8+ T cells from the blood of mice demonstrating the gates used and percentage of positive cells. (C) FACS analysis of blood cells at 2 weeks post-castration showing total T cell, CD4+ T cell, CD8+ T cell and B cell counts (monocytes and macrophages not shown) for sham and Cx mice, n = 4. **P < 0.01 compared to sham group. (D) Representative scatter plot of flow cytometric analysis of CD4+ and FoxP3+ T cells from blood of mice demonstrating the gates used and percentage of positive cells. (E) FACS analysis of blood CD4+ FoxP3+ T cell (Treg) counts for sham and Cx mice, n = 4.

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