Figure 4
Effect of thymic stimulation by castration on glial cell activation in spinal cords of male SOD1 G93A mice. Immunohistochemical analysis of lumbar spinal cords of wild-type (WT) or sham and castrated (Cx) SOD1G93A mice at 120 days for (A) GFAP and (B) CD11b. Astrocytic activation identified by GFAP is increased in sham SOD1G93A mice, but not affected by castration. Microglial activation shown by CD11b is increased in sham SOD1G93A mice and reduced by castration. Scale bar = 30 μm. Representative photomicrographs from two mice per group are shown.