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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice

Figure 6

Castration and mutant SOD1 expression reduces androgen receptor protein level in spinal cords of SOD1 G93A mice. (A) Western blot analysis of AR expression levels in lumbar spinal cords of wild-type (WT) and SOD1G93A mice at 60, 90 and 120 days. (B) Quantification of AR expression from (A) is shown. Data are mean ± SEM normalised to β-actin and expressed as percentage of WT mice. n = 4, *P < 0.05 compared to WT mice. (C) Western blot analysis of AR and SOD1 expression in lumbar spinal cords of sham and castrated (Cx) SOD1G93A mice at 120 days. (D) Quantification of AR expression from (C) is shown. Data are mean ± SEM normalised to β-actin and expressed as percentage of sham mice. n = 4 to 5, **P < 0.01 compared to sham group.

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