Figure 7
Androgen receptor expression is reduced in spinal motor neurons by mutant SOD1 action and castration in mice. Immunohistochemical analysis of lumbar spinal cords of wild-type (WT) or sham and castrated (Cx) SOD1G93A mice at 120 days for androgen receptor (AR) and motor neurons (NeuN). AR is mainly localised within the cytoplasm of motor neuron cell bodies in WT mice. AR expression is reduced in motor neurons of SOD1G93A mice and redistributed to axons and/or dendrites and further depleted in Cx SOD1G93A mice. Scale bar = 30 μm.