Figure 7

FK506 and tat-VIVIT decreased spleen cytokine levels in APP/PS1 mice. Twelve-month-old male APP/PS1 mice were treated via subcutaneous delivery for 28 days with no treatment (control), vehicle DMSO, 1 mg/kg/day FK506, 0.5 mg/kg/day VIVIT, or 0.5 mg/kg/day negative control scrambled peptide, VEET (n = 6 to 8/condition). Spleens were collected, lysed, and used for TNFα, IL-1β, and IL-6 ELISAs. (*p < 0.05, **p < 0.01 from control; ^$ p < 0.01, ^$$ p < 0.01 from vehicle; +p < 0.05 from VIVIT; &&p < 0.01 from FK506)