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Table 1 CSF cytokine concentrations in infected animals treated with RS or vehicle (Ctrl)

From: The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis

  Ctrl, 18 hpi ( n= 11) RS, 18 hpi ( n= 10) P value b Ctrl, 27 hpi ( n= 8) RS, 27 hpi ( n= 7) P value b
TNF [ng/ml]a 9.8 ± 4.0 (7.4, 5.3, 15.1) 8.9 ± 4.6 (8.0, 2.0, 17.1) 0.93 2.8 ± 2.3 (1.9, 0.9, 8.0) 1.8 ± 1.2 (1.1, 0.9, 4.3) 0.32
IL-6 [ng/ml]a 228 ± 67.4 (241, 127, 349) 173 ± 62.1 (166, 89.8, 299) 0.061 126 ± 96.0 (90.0, 27.1, 268) 120 ± 113 (60.5, 27.5, 317) 0.92
IL-1β [ng/ml]a 6.6 ± 2.7 (6.4, 2.2, 11.1) 3.6 ± 1.6 (3.8, 1.5, 6.3) 0.0079** 5.3 ± 3.8 (4.7, 0.6, 9.7) 3.7 ± 2.5 (3.1, 1.2, 8.0) 0.52
IL-10 [pg/ml]a 237 ± 118 (294, 30.0, 389) 70.2 ± 84.8 (30.0, 30.0, 243) 0.0051** 776 ± 806 (581, 30.0, 2,318) 500 ± 608 (30.0, 30.0, 1,297) 0.33
IFN-γ [ng/ml]a 7.0 ± 4.6 (8.0, 0.38, 13.3) 5.7 ± 5.4 (5.1, 0.38, 16.9) 0.48 8.9 ± 8.8 (7.3, 0.38, 20.0) 7.3 ± 7.0 (5.3, 0.38, 19.6) 0.86
  1. aValues are mean ± standard deviation (median, minimum, maximum); bMann-Whitney U test. hpi, hours post infection; TNF, tumour necrosis factor α; IL, interleukin; IFN, interferon. **Statistically significant difference (P < 0.01).