Table 1 CSF cytokine concentrations in infected animals treated with RS or vehicle (Ctrl)
Ctrl, 18 hpi ( n = 11) | RS, 18 hpi ( n = 10) | P value b | Ctrl, 27 hpi ( n = 8) | RS, 27 hpi ( n = 7) | P value b | |
|---|---|---|---|---|---|---|
TNF [ng/ml]a | 9.8 ± 4.0 (7.4, 5.3, 15.1) | 8.9 ± 4.6 (8.0, 2.0, 17.1) | 0.93 | 2.8 ± 2.3 (1.9, 0.9, 8.0) | 1.8 ± 1.2 (1.1, 0.9, 4.3) | 0.32 |
IL-6 [ng/ml]a | 228 ± 67.4 (241, 127, 349) | 173 ± 62.1 (166, 89.8, 299) | 0.061 | 126 ± 96.0 (90.0, 27.1, 268) | 120 ± 113 (60.5, 27.5, 317) | 0.92 |
IL-1β [ng/ml]a | 6.6 ± 2.7 (6.4, 2.2, 11.1) | 3.6 ± 1.6 (3.8, 1.5, 6.3) | 0.0079** | 5.3 ± 3.8 (4.7, 0.6, 9.7) | 3.7 ± 2.5 (3.1, 1.2, 8.0) | 0.52 |
IL-10 [pg/ml]a | 237 ± 118 (294, 30.0, 389) | 70.2 ± 84.8 (30.0, 30.0, 243) | 0.0051** | 776 ± 806 (581, 30.0, 2,318) | 500 ± 608 (30.0, 30.0, 1,297) | 0.33 |
IFN-γ [ng/ml]a | 7.0 ± 4.6 (8.0, 0.38, 13.3) | 5.7 ± 5.4 (5.1, 0.38, 16.9) | 0.48 | 8.9 ± 8.8 (7.3, 0.38, 20.0) | 7.3 ± 7.0 (5.3, 0.38, 19.6) | 0.86 |