Figure 5

LPS alters neuromodulator action on cortical networks. (A) Low and high concentrations of bolus neuromodulator application demonstrate an LPS-mediated concentration-dependent increase in the rate of response recovery. (Minimum of 24 slices from eight animals in each group; *P < 0.05, unpaired t-test) (B) Histograms comparing the normalized recovery of the first pulse as determined by the average of five stimulations demarcated by the grey-shaded boxes in (A) (*P < 0.05, Scheffé’s multiple comparison) ACh, acetylcholine; NE, norepinephrine; 5-HT, serotonin; LPS, lipopolysaccharide; P1, pulse 1; P2, pulse 2.