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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity

Figure 6

Changes in GABA A -mediated inhibition do not account for LPS-mediated changes in neuromodulator action. Time series of the bicuculline-sensitive neuromodulator effects under control and LPS pretreatment conditions is plotted for comparison. Neuromodulator application in the presence of bicuculline (2 μm in perfusate) was subtracted from the time series of neuromodulator application before bicuculline administration (N = 5 slices from five animals; *P < 0.05, unpaired t-test). 5-HT, serotonin; ACh, acetylcholine; NE, norepinephrine; P1, pulse 1; P2, pulse 2; LPS, lipopolysaccharide.

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Journal of Neuroinflammation

ISSN: 1742-2094