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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity

Figure 8

Pharmacological inhibition of ACh-E blocks LPS-mediated increases in recovery of ACh-mediated effects. (A) Time series plots of normalized pulse 1 and 2 amplitudes in the absence and presence of the ACh-E inhibitor donepezil illustrating the loss of an LPS-mediated enhancement in recovery of ACh-mediated effects (*P < 0.05, unpaired t-test). (B) Histograms comparing the normalized recovery of the first pulse as determined by the average of five stimulations demarcated by the grey-shaded boxes in (A) (*P < 0.05, Scheffé’s multiple comparison) (N = 14 slices from five animals in saline group, N = 15 slices from four animals in LPS group). ACh, acetylcholine; con, control; aCSF, artificial cerebral spinal fluid; don, donepezil; LPS, lipopolysaccharide; P1, pulse 1; P2, pulse 2.

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