Figure 2

The effect of central infusion of AT2-R antagonist PD123,319 on DOCA/salt-induced hypertension in female rats. Daily mean arterial pressures (MAP) (A) and heart rate (HR) (B) before and during DOCA/salt treatments in intact females with or without central infusions of PD123,319. (C,D). Average changes in MAP and HR induced by DOCA/NaCl treatment in all groups. *P < 0.05 compared to baseline, ^# P < 0.05 compared to females with central infusion of PD123,319. DOCA, deoxycorticosterone acetate; icv, intracerebroventricular.