The effect of central infusion of AT2-R antagonist PD123,319 on DOCA/salt-induced hypertension in male rats. Daily mean arterial pressures (MAP) (A) and heart rate (HR) (B) before and during DOCA/salt treatments in male rats with or without central infusions of PD123,319. Average changes in MAP and HR induced by DOCA/salt treatment in all groups (C,D). *P < 0.05 compared to females with central infusion of PD123,319 alone. DOCA, deoxycorticosterone acetate; icv, intracerebroventricular.