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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation

Figure 4

Chronic LPS infusion increased hippocampal synaptosomal uptake of 45 Ca +2 and this increase was reduced by treatment with nimodipine in vivo (A) or ex vivo (B and C). (A) Baseline 45Ca+2 uptake by hippocampal synaptosomes isolated from rats infused with LPS or aCSF for 4 weeks and treated with vehicle or nimodipine. (B) 45Ca+2 uptake by hippocampal synaptosomes isolated from rats infused with LPS or aCSF for 4 weeks and treated with vehicle or nimodipine and additionally treated with ex vivo application of 30 μM nimodipine. (C) Data from figures (A) and (B) for comparison of baseline uptake and blocked uptake of 45Ca+2 with ex vivo nimodipine. Data expressed as mean ± SEM. *Indicates a significant difference from treatment-matched aCSF controls, †Indicates a significant difference from LPS + vehicle rats, N.S. indicates no significant differences. Significance determined by P < 0.05. LPS lipopolysaccharide, aCSF artificial cerebrospinal fluid.

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