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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro

Figure 5

Knockdown of IRF7 in human BE(2) M17 neuroblastoma cells confers protection against Aβ1-42. Human BE(2) M17 neuroblastoma cells, transfected with an IRF7 knockdown (KD) construct or negative control (NC) plasmid, were treated with 2.5 to 15 μM Aβ-42 for 72 h and an MTS assay to measure cell viability was performed (**p < 0.01, n = 5, unmatched two-way ANOVA, Bonferroni post hoc test). All data is displayed as mean ± SEM with treatment concentration on the x axis.

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