Representative images of
immunostained for GFAP (A, B, C, D), HLA-DR (E, F, G, H), MT-I/II (I, J, K, L), and AQP4 (M, N, O, P) from patients with MTLE
(A, E, I, M), MTLE + D (B, F, J, N), MTLE + P (C, G, K, O) and autopsy controls (D, H, L, P). Observe the increased astroglial reaction (A, B, C), microglial activation (E, F, G), MT-I/II immunopositive astrocytes (I, J, K), and reduced perivascular aquaporin 4 (M, N, O) in MTLE groups (MTLEW, MTLE + D, and MTLE + P), when compared to the respective staining pattern of the CTRL group (D, H, L, P). Bar in (P) indicates 150 μm. AQP4 = aquaporin 4; CTRL = control; GFAP = glial fibrillary acidic protein; HLA-DR = human leukocyte antigen, MHC class II; MT-I/II = metallothionein-I/II; MTLE = mesial temporal lobe epilepsy; MTLE + D = MTLE + major depression; MTLE + P = MTLE + interictal psychosis; MTLEW = MTLE subjects without psychiatric history.