Immunopositive area fraction of MT-I/II (A) and AQP4 (B) in the hippocampal subfields of MTLE
(black boxplots), MTLE + D (dark gray boxplots), MTLE + P (light gray boxplots), and control group (white boxplots). (A) MTLEW cases had higher MT-I/II immunopositive area in the PAR (compared to all other groups), CA1 (compared to CTRL and MTLE + P), IML, CA2, ERC (compared to CTRL), and in GCL (compared to MTLE + P). (B) Decreased AQP4 area was observed in the hilus of all MTLE groups, in CA4 of MTLE + P, and in the SUB of MTLEW and MTLE + P (compared to CTRL). AQP4 = aquaporin 4; ERC = entorhinal cortex; GCL = granule cell layer; HIL = hilus; IML = inner molecular layer; MT-I/II = metallothionein-I/II; MTLE = mesial temporal lobe epilepsy; MTLE + D = MTLE + major depression; MTLE + P = MTLE + interictal psychosis; MTLEW = MTLE subjects without psychiatric history; OML = outer molecular layer; PAR = parasubiculum; PRO = prosubiculum; SUB = subiculumS. *Indicates difference from CTRL; #indicates difference from MTLE + D; xindicates difference from MTLEW; and +indicates difference from MTLE + P.