Figure 2

Box plots showing serum levels of HMGB1 in the whole MS group and controls (A) and in MS patients with different clinical forms of MS (B). Serum levels of HMGB1 were measured using a commercially available ELISA, as described in ‘Methods.’ For the sake of clarity, only significant P values are shown in the graphs. Number of individuals included in the study is shown in parentheses. Eleven patients with RRMS, five with SPMS, and eight with PPMS were also included in the HMGB1 gene expression study. HC: healthy controls. MS: whole group of multiple sclerosis patients. RR: relapsing-remitting MS. SP: secondary progressive MS. PP: primary progressive MS.