Figure 3From: Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage CNS autoimmune inflammation leads to increased bioluminescence in oLucR mice at clinical onset of disease. (a) EAE disease scores in MOG-immunized oLucR animals (mean ± SEM, n = 5). (b) Ratio of mean CNS-specific bioluminescence between MOG-immunized and control mice imaged in an IVIS every 2 to 3 days after immunization. Data are representative of three independent experiments (n = 15). The red line indicates the baseline photon emission before MOG immunization. (c) Linear correlation between day of clinical onset and increase of bioluminescence in MOG-immunized oLucR mice (n = 15, Pearson’s correlation coefficient = 0.9989). The three mice with disease onset around day 40 did not develop clinically overt EAE after the initial EAE induction and therefore were re-immunized with MOG peptide after 1 month. (d) Ratio of mean CNS-specific bioluminescence between PT-treated and control mice. oLucR mice were injected with 300 ng PT at day 0 and 2 and bioluminescence acquired over time (n = 5). The red line indicates baseline photon emission before PT administration.Back to article page