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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Role for cFMS in maintaining alternative macrophage polarization in SIV infection: implications for HIV neuropathogenesis

Figure 4

Parenchymal CD163 + microglia, but not perivascular or nodular CD163 + MΦs, express IL-34 in FWM of rhesus macaques with SIVE. In white matter, CD163+ microglia (A), as well as other glia (B), express IL-34 (C). IL-34 expression appears to be limited to cells within the vicinity of perivascular cuffs (E), as CD163+ MΦs that accumulate perivascularly (D) do not appear to express appreciable levels of IL-34 (F). In contrast to perivascular cuffs, IL-34 is more highly expressed within nodular lesions (H). These lesions are comprised largely of CD163+ MΦs (G), however, little overlap with IL-34 is observed (I).

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