Skip to main content
Figure 5 | Journal of Neuroinflammation

Figure 5

From: Role for cFMS in maintaining alternative macrophage polarization in SIV infection: implications for HIV neuropathogenesis

Figure 5

Normal neuronal M-CSF and IL-34 expression is altered in SIV and SIVE. Cells with neuronal morphology in frontal grey matter (FGM) of rhesus macaques express M-CSF (A, B, C; red) and IL-34 (D, E, F; red), regardless of the presence of SIV infection. Panels are shown at ×400 under oil. Bioquantification analyses reveal neuronal M-CSF expression is significantly decreased in brain of SIV-infected animals, with (P = 0.0026) and without (P = 0.0085) encephalitis, as compared to seronegative controls (G). In contrast to M-CSF, IL-34 quantification suggests an increase in neuronal IL-34 expression in animals with SIVE, as compared to seronegative and SIV-infected animals (H); however, this did not reach statistical significance in this small study. Data points represent the average percent expression per animal of immunohistochemical staining in twelve randomly selected 0.31 mm2 fields of brain tissue from two seronegative (•), four SIV+ (■), and four SIVE (▲) animals.

Back to article page