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Table 3 mRNA microarray analysis of CBD and MOG35-55 modulation of T MOG cell activity

From: Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells

Gene Full name MOG (fold change) MOG + CBD (fold change) CBD (fold change)
Lag3 Lymphocyte-activation gene 3 1.7 5.2 1.7
Icos Inducible T-cell costimulator 1.6 2.3 2.1
Nfatc1 Nuclear factor of activated T-cells, cytoplasmic 1 3.3 4.0 1.3
Ndrg1 N-myc downstream-regulated gene 1 6.2 6.7 2.5
Cdkn1a Cyclin-dependent kinase inhibitor 1A 2.6 3.1 1
Casp4 (Casp11) Caspase 4, apoptosis-related cysteine peptidase 2.2 2.7 2.1
Fas Fas cell surface death receptor 2.6 3.3 1.3
Ccl4 Chemokine (C-C motif) ligand 4 9.1 9 0.9
  1. TMOG/adherent APC co-cultures were stimulated with MOG35-55 in the presence or absence of CBD. mRNA from CD4+ microbead purified TMOG cells was subjected to microarray analysis. The table presents the genes significantly upregulated by MOG35-55 and their modulation by CBD (P < 0.005). The data are expressed as fold change vs purified TMOG cells that were not stimulated by MOG35-55 when co-cultured with APC. Numbers in bold indicate significant effect of CBD vs the MOG35-55-induced effect. Values in italics indicate significant effects of CBD vs non-stimulated TMOG cells (P < 0.005).
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Journal of Neuroinflammation

ISSN: 1742-2094