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Table 3 mRNA microarray analysis of CBD and MOG35-55 modulation of T MOG cell activity

From: Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells

Gene

Full name

MOG (fold change)

MOG + CBD (fold change)

CBD (fold change)

Lag3

Lymphocyte-activation gene 3

1.7

5.2

1.7

Icos

Inducible T-cell costimulator

1.6

2.3

2.1

Nfatc1

Nuclear factor of activated T-cells, cytoplasmic 1

3.3

4.0

1.3

Ndrg1

N-myc downstream-regulated gene 1

6.2

6.7

2.5

Cdkn1a

Cyclin-dependent kinase inhibitor 1A

2.6

3.1

1

Casp4 (Casp11)

Caspase 4, apoptosis-related cysteine peptidase

2.2

2.7

2.1

Fas

Fas cell surface death receptor

2.6

3.3

1.3

Ccl4

Chemokine (C-C motif) ligand 4

9.1

9

0.9

  1. TMOG/adherent APC co-cultures were stimulated with MOG35-55 in the presence or absence of CBD. mRNA from CD4+ microbead purified TMOG cells was subjected to microarray analysis. The table presents the genes significantly upregulated by MOG35-55 and their modulation by CBD (P < 0.005). The data are expressed as fold change vs purified TMOG cells that were not stimulated by MOG35-55 when co-cultured with APC. Numbers in bold indicate significant effect of CBD vs the MOG35-55-induced effect. Values in italics indicate significant effects of CBD vs non-stimulated TMOG cells (P < 0.005).
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Journal of Neuroinflammation

ISSN: 1742-2094