Skip to main content
Figure 2 | Journal of Neuroinflammation

Figure 2

From: Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways

Figure 2

Effect of a TLR2/4 inhibitor on inflammation induced by B. burgdorferi in microglia. Primary microglia were pretreated with 10 μg/mL OxPAPC, a TLR2/4 inhibitor, for 2 h, followed by B. burgdorferi for an additional 24 h. The inhibitor was co-incubated with the bacterium for the duration of infection. After 24 h, the supernatants were collected and stored until analysis. Data are representative of three independent experiments with microglia cultured from two animals. LPS and Pam3CSK4 are positive controls for the inhibitor with the medium serving as control for baseline expression. Bars represent standard deviation. *P < 0.05; **P < 0.01; ***P < 0.001. CCL2, chemokine (C-C) motif ligand 2; CXCL8, chemokine (C-X-C) motif ligand 8; IL-6, interleukin 6; LPS, lipopolysaccharide; OxPAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine.

Back to article page