Figure 7

Analgesic effects and MCP-1 expression with co-treatment of TIIAS and SP600125 in SNL rats. SP600125, a specific JNK inhibitor, was injected intrathecally at POD 3 to POD 10 (n = 12 for each group). Intrathecal administration of SP600125 significantly increased the mechanical PWT compared with the vehicle control, and co-treatment with TIIAS and SP600125 did not lead to more significant increases in mechanical PWT compared with the TIIAS-alone group (A). And also, co-treatment with TIIAS and SP600125 did not result in further inhibition of MCP-1 compared with TIIAS-alone group (B). Data (A) are presented as mean ± SEM (*P < 0.05, n = 12, vs vehicle group, repeated measures ANOVA). Data (B) are presented as mean ± SD (*P < 0.05, vs SNL-vehicle group, n = 4). SNL, spinal nerve ligation; TIIAS, tanshinone IIA sulfonate; Veh, vehicle; MCP-1, monocyte chemoattractant protein-1; SP, sodium pyruvate.