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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain

Figure 3

Time course of the effects of i.t. Ad-antisense PTEN on nociceptive behaviors in normal rats. The naïve rats exhibited mechanical allodynia (B) but not thermal hyperalgesia (A) and cold allodynia (C) from 3 to 7 days after i.t. injection of Ad-antisense PTEN. These data indicate the importance of downregulation of spinal PTEN for nociception. Each point represents the mean ± SEM with six rats per group. *P < 0.05 compared with vehicle group. Ad-GFP, adenovirus-mediated green fluorescent protein; Ad-PTEN, adenovirus-mediated phosphatase and tensin homolog deleted from chromosome 10; Ad-antisense PTEN, adenovirus-mediated PTEN antisense oligonucleotide.

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