The effects of i.t. Ad-PTEN on nociceptive behaviors with the contralateral hindpaw in CCI rats. I.t. Ad-PTEN did not significantly affect the responses to thermal hyperalgesia (A), mechanical allodynia (B), or cold allodynia (C) tests. Each point represents the mean ± SEM with six rats per group. Ad-GFP, adenovirus-mediated green fluorescent protein; Ad-PTEN, adenovirus-mediated phosphatase and tensin homolog deleted from chromosome 10; CCI, chronic constriction injury; i.t., intrathecal.