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Table 1 Effects of CYM-5541 on membrane potential

From: Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

CYM-5541 concentration Untreated control (mV) Posttreatment (mV) n
100 nM −55.5 ± 2.4 −52.8 ± 1.9 5
1 μM −53.9 ± 1.0 −50.5 ± 1.8 6
10 μM −51.6 ± 1.0 −48.1 ± 1.8 6
30 μM −55.5 ± 1.8 −18.6 ± 2.9* 9
1 μM W146 + 30 μM −61.7 ± 2.5 −52.0 ± 5.6 4
10 μM W146 + 30 μM −52.9 ± 1.2 −47.8 ± 4.0 3
  1. *P < 0.05 paired t-test; n = number of neurons.