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Table 3 Comparison of IGFs and related proteins in plasma and CSF in subjects with or without neurocognitive impairment

From: Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals

  Factors All subjects NC impaired NC unimpaired P value
( n= 107) ( n= 58) ( n= 49)
Plasma IGF1 (mean ± SD, ng/ml) 192.5 ± 55.3 186.0 ± 63.28 200.1 ± 43.7 0.127
IGF2 (mean ± SD, ng/ml) 703.3 ± 165.2 686.1 ± 170.5 723.3 ± 158.3 0.520
log IGFBP1 (mean ± SD, ng/ml)a 1.43 ± 0.74 1.45 ± 0.85 1.40 ± 0.59 0.797
IGFBP2 - median (IQR) 33.97 38.59 26.00 0.346
(14.44 to 51.76) (16.13 to 47.72) (6.54 to 54.39)
log IGF2R (mean ± SD, ng/ml)a 4.51 ± 0.88 4.47 ± 0.97 4.56 ± 0.77 0.716
CSF IGF1 - median (IQR) 1.11 (0.92 to 1.48) 1.11 (0.88 to 1.48) 1.13 (0.92 to 1.51) 0.821
log IGF2 (mean ± SD, ng/ml)a 3.70 ± 0.17 3.72 ± 0.17 3.68 ± 0.17 0.345
IGFBP1 - median (IQR) 0.48 (0.35 to 0.77) 0.50 (0.37 to 0.75) 0.47 (0.33 to 1.59) 0.880
log IGFBP2 (mean ± SD, ng/ml)a 4.35 ± 0.37 4.35 ± 0.32 4.36 ± 0.41 0.986
IGF2R0.5 (mean ± SD, ng/ml)b 2.56 ± 0.84 2.51 ± 0.87 2.62 ± 0.80 0.498
  1. aPlasma IGFBP1, plasma IGF2R, CSF IGF2 and CSF IGFBP2 were transformed with natural logarithms; bCSF IGF2R was square root transformed. IQR, interquartile range.