Functional efficacy of MW151 to suppress CHI-induced cognitive impairment. (A) Overview of study design. MW151 (5 mg/kg i.p.) was administered either as a single acute treatment at 6 h p.i. or in a more extended treatment paradigm (3 h, 6 h, then once daily for 7 days p.i.). (B) Mice were tested for cognitive deficits in the RAWM starting at 14 days p.i. (n = 23 sham; n = 27 CHI + veh; n = 12 CHI + MW150 acute; n = 14 CHI + MW150 chronic).