Table 1 Rodent models of neuroinflammation
From: Rodent models of neuroinflammation for Alzheimer’s disease
Models | Predisposing factors/causes | Time of appearance of lesions | Signs (time detectable) | SLC reading key | Reference | |
|---|---|---|---|---|---|---|
hp-Tau | Aβ depositions | |||||
LPS | Peripheral immune challenge, chronic neuroinflammation | ? | ? | Fear memory (?) | S1L0C1 | [165] |
Spatial memory (?) | ||||||
PolyI:C | Peripheral immune challenge, chronic neuroinflammation | 3m | 12m | Spatial memory (20 m) | S1L1C1 | [5] |
(PHF, but not NFTs) | (APP depositions) | |||||
ICV-STZ | Disrupted insulin signaling, chronic neuroinflammation | 6-7w | 12w | Spatial memory | S1L1C1 | [85] |
Visual recognition memory (3w) | ||||||
ICV-OKA | Inhibition of serine/threonine phosphatases 1 and 2A | 2w | 6w | Spatial memory (?) | S1L1C0 | |
(PHF, but not NFTs) | (Non-fibrillar Aβ deposits) | |||||
ICV-colchicine | Inhibition of tubulin formation/microtubule breakdown | ? (Tau dephosphorylation) | ? (Amyloid plaque) | Spatial memory (14d to 21d) | S1L0C1 | |
p25 Tg | Upregulation of cPLA2, neuroinflammation | 4w | 8w | Contextual fear memory (6w) | S1L1C1 | [145] |
IL-1 β Tg | Chronic neuroinflammation | ? | ? (Increased clearance of amyloid plaques) | Contextual fear memory (12w) | S1L0C0 | [39] |
Anti-NGF antibody Tg | Blockade of NGF signaling pathway | ? (Neurofibrillary pathology) | ? (Amyloid plaques) | Visual recognition memory (4 m); Spatial memory (9 m) | S1L1C0 | |