Mice
|
MCAO, 60-min ischemia, 24-h reperfusion
|
72 h/12-min ischemia
|
Ischemic preconditioning
|
Decrease brain infarction volume, and IRF gene participate in brain protection
|
Stevens SL
|
[79]
|
Mice
|
MCAO, 60-min ischemia, 6-h reperfusion
|
24 h/IP
|
TLR2, Pam3CSK4
|
Decrease brain infarction and edema, improve neurological function, and maintain BBB function
|
Hua F
|
[60]
|
Mice
|
MCAO, 45-min ischemia, 24-h reperfusion
|
72 h/subcutaneous injection
|
TLR3, poly-ICLC
|
Decrease brain infarction volume and improve neurological function
|
Packard AEB
|
[63]
|
Mice
|
MCAO, 120-min ischemia, 22-h reperfusion
|
24 h/systemic injection
|
TLR3 poly-IC
|
Decrease brain infarction volume and neurological defect and lower the levels of TNF-α and IL-6 in cortex and striatum
|
Pan LN
|
[66]
|
Mice
|
MCAO, 60-min ischemia, 24-h reperfusion
|
1 h/IP
|
TLR3 poly-IC
|
Decrease brain infarction and prevention of Fas/FADD interaction
|
Zhang X
|
[67]
|
Spontaneously hypertension rats
|
MCAO, 120-min ischemia, 22-h reperfusion
|
2, 3, 4 days/IV
|
TLR4 LPS
|
Decrease brain infarction volume, mediated by TNF-α
|
Tasaki K
|
[72]
|
Mice
|
MCAO, 120-min ischemia, 47-h reperfusion
|
48 h/IP
|
TLR4 LPS
|
Decrease brain infarction volume, inhibit the infiltration of neutrophil and activation of the microglia
|
Rosenzweig HL
|
[73]
|
Mice
|
MCAO, 40-, 45-, 60-min ischemia, 24-h reperfusion
|
72 h/IP
|
TLR4 LPS
|
Decrease brain infarction volume that was mediated by IRF3
|
Marsh B
|
[61]
|
Mice
|
MCAO, 40-to 60-min ischemia, 24-h reperfusion
|
72 h/subcutaneous injection
|
TLR4 LPS
|
Decrease brain infarction volume, and TRIF-IRF3 play vital role
|
Vartanian KB
|
[58]
|
Mice
|
MCAO, 60-min ischemia, 24-h reperfusion
|
72 h/IP
|
TLR4
|
Decrease brain infarction volume, and inhibit TNF-α signaling pathway after cerebral ischemia
|
Rosenzweig HL
|
[76]
|
Mice
|
MCAO, 45-to 60-min ischemia, 23-h reperfusion
|
72 h/subcutaneous injection
|
TLR7 GDQ
|
Decrease brain infarction volume and neurological functional score that was protected through I type interferon
|
Leung PY
|
[62]
|
Mice
|
MCAO, 60-min ischemia, 72-h reperfusion
|
30 min/IV
|
TLR8 R848
|
Increase neurological function defect and mortality, activate pro-apoptotic JNK pathway and inflammation
|
Tang SC
|
[56]
|
Mice
|
MCAO, 60-min ischemia, 24-h reperfusion
|
72 h/IP
|
TLR9 CpG-ODN
|
Decrease brain infarction volume and TNF-α play a vital role
|
Stevens SL
|
[64]
|
Mice
|
MCAO, 60-min ischemia, 24-h reperfusion
|
72 h/IP or subcutaneous injection
|
TLR9 CpG-ODN
|
Decrease brain infarction volume and IRF gene participate in cerebral protection after ischemia
|
Stevens SL
|
[79]
|
Mice
|
MCAO, 60-min ischemia, 24-h reperfusion
|
1 h/IP
|
TLR9 CpG-ODN
|
Decrease brain infarction and activation of PI3K/Akt signaling
|
Lu C
|
[78]
|