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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model

Fig. 8

EA increased expression of Nrf2 and its downstream factors in the midbrain and striatum of A53T mice. a and b Effects of EA on Nrf2, HO-1 and GCLM protein expression in the midbrain (a) and striatum (b). Representative immunoblots are shown above the quantified data. Note that EA significantly reversed the reduction of three proteins in A53T mice. c Effects of EA on Nrf2, HO-1, and GCLM mRNA expression in the midbrain. EA produced the similar recovery of reduced Nrf2 and HO-1 mRNA expression in A53T mice. Data are expressed by means ± SEM (n = 4 per group). *P < 0.05 vs. nTg group. ##P < 0.01, ###P < 0.001vs. A53T group

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