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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation

Figure 4

Representative Western blotting showing phosphorylation of eNOS at serine 1179 in response to stimulation with 20 ng/ml VEGF of BAECs cultured for 24 h in the presence of 10 μM Aβ25–35 (A) or 5 μM Aβ1–42 (B) in combination with 2 mM NAC. (C-D) The blots were subjected to densitometric analysis, and the obtained data were analyzed for statistical significance in comparison to the data shown in Figure 1A,B. (*P < 0.05 versus 0 min of each separate treatment group, n = 3). VEGF, vascular endothelial growth factor; eNOS, endothelial nitric oxide synthase; min, minutes; NAC, N-acetyl-cysteine.

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Journal of Neuroinflammation

ISSN: 1742-2094